Landmark trials for Internist in Q1 2008

The Q1 of this year has seen lot of landmark studies being published. I have added a few studies which should be remembered in daily patient care.
ONTARGET, ENHANCE, HYVET, CREATE registry(INDIA)

First off the ONTARGET, one of the largest antihypertensive trials done to date to answer one of the always eluding questions of combination ACEI and ARB therapy and which is better ACEI or ARB. Results showed

Telmisartan is as efficacious as (or non inferior to) Ramipril in Hypertension management. Also, combination therapy is associated with symptomatic hypotension, more hyperkalemia and renal dysfunction.

Will post on the other landmark trials in the next post.